Autologous Hematopoietic Stem Cell Transplantation for Treatment of Systemic Sclerosis

High-Dose Immunosuppressive Therapy and Autologous Hematopoietic Stem Cell Transplantation for Treatment of Severe Systemic Sclerosis

Hematopoietic Stem Cell Transplantation for Thalassemia

Thalassemia is an autosomal recessive disorder associated with defective synthesis of the α- or β-chain of hemoglobin. For β-thalassemia major patients, therapeutic options are either monthly red cell transfusions and chelation therapy or allogeneic stem cell transplant. Stem cell transplant is the only curative approach and success is inversely correlated with the degree of iron overload and h...

Pediatric Hematopoietic Stem Cell Transplantation

The introduction and evolution of hematopoietic stem cell transplantation (HSCT) could be traced back to 1950s, to the studies on interactions among irradiation, covering spleen and bone marrow from it and injection of bone marrow cells. Today, HSCT is considered a well-established, effective and promising means of therapy for various malignant and non-malignant medical conditions, both in chil...

Autologous stem cell transplantation in systemic sclerosis: a systematic review.

OBJECTIVES Haematopoetic autologous stem cell transplantation (ASCT) has emerged as a treatment option for patients with refractory, severe autoimmune disease. This is a systematic review of the current literature on ASCT in adult patients with systemic sclerosis (SSc). METHODS Original articles published between 2005 and 2016 that evaluated the use of ASCT in patients with SSc were reviewed ...

Autologous hematopoietic stem cell transplantation as a treatment option for aggressive multiple sclerosis.

OPINION STATEMENT Despite the development of several injectable or oral treatments for relapsing-remitting multiple sclerosis (RRMS), it remains difficult to treat patients with aggressive disease, and many of these continue to develop severe disability. During the last two decades autologous hematopoietic stem cell transplantation (aHSCT) has been explored with the goal to eliminate an aberran...